产品说明
一般描述
Caldesmon is a protein that facilitates the regulation of cellular contraction through complexing with calmodulin, tropomyosin, and actin. Its high molecular weight isoform (h-caldesmon) has been identified to have restricted expression in visceral and vascular smooth muscle cells. In particular, strong expression of h-caldesmon has been observed in non-neoplastic uterine myometrium while being entirely absent in the endometrial layer. In spindle cell tumor pathology, overlapping immunohistochemical staining profiles between smooth muscle cells and myofibroblastic cells has not allowed for reliable identification of true smooth muscle tumors. Immunohistochemical detection of h-caldesmon has been demonstrated to aid in the distinguishing smooth muscle tumors, such as leiomyoma and leiomyosarcoma from myofibroblastic lesions, such as inflammatory myofibroblastic tumors and fibromatoses.
质量
 IVD |  IVD |  IVD |  RUO |
外形
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.
制备说明
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其他说明
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
法律信息
Cell Marque is a trademark of sigma-aldrich Co. LLC
产品性质
| 质量水平 | 500 100 |
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | diluted ascites fluid |
| antibody product type | primary antibodies |
| 克隆 | hHCD, monoclonal |
| 描述 | For In Vitro Diagnostic Use in Select Regions |
| 形式 | buffered aqueous solution |
| species reactivity | human |
| 包装 | vial of 0.1 mL concentrate (451M-14) vial of 0.1 mL concentrate Research Use Only (451M-14-RUO) vial of 0.5 mL concentrate (451M-15) vial of 1.0 mL concentrate (451M-16) vial of 1.0 mL concentrate Research Use Only (451M-16-RUO) vial of 1.0 mL pre-dilute Research Use Only (451M-17-RUO) vial of 1.0 mL pre-dilute ready-to-use (451M-17) vial of 7.0 mL pre-dilute ready-to-use (451M-18) vial of 7.0 mL pre-dilute ready-to-use Research Use Only (451M-18-RUO) |
| manufacturer/tradename | Cell Marque™ |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 (concentrated) |
| 同位素/亚型 | IgG1 |
| 控制 | bladder, colon, leiomyoma, smooth muscle tumors, stomach |
| 运输 | wet ice |
| 储存温度 | 2-8℃ |
| 可视化 | cytoplasmic |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
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