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位置:首页 > 品牌 > Sigma-Aldrich > Nestin (10C2) Mouse Monoclonal Antibody

Nestin (10C2) Mouse Monoclonal Antibody

品牌
Sigma-Aldrich
货号
388M-1
包装型号
规格纯度
参考价格
3176.96 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Nestin (10C2) Mouse Monoclonal Antibody
产品介绍:

产品说明

一般描述

Nestin is a class VI intermediate filament (IF) protein. It has been reported that nestin expression is significantly increased in melanoma and correlated with more advanced stages of the disease. An immunohistochemical analysis identified nestin-positive cells in 84% (35/42) of primary melanoma and 83% (10/12) of metastatic melanoma. Nestin immunoreactivity was also observed in melanoma cells in all (10/10) cases of HMB-45-negative amelanotic and melanotic, non-desmoplastic melanoma. Nestin expression has been reported in tumors of the CNS, including astrocytoma, ependymoma, oligodendroglioma, glioblastoma, and primitive neuroectodermal tumors. Nestin has been detected in human gliomas, including low and high grade, but its expression is observed more frequently in high grade than in low grade gliomas. Nestin overexpression is seen in carcinomas, including prostatic adenocarcinoma, pancreatic ductal carcinoma, thyroid carcinoma, and in mesenchymal tumors such as GIST and DFSP. Among the breast carcinoma subtypes, nestin is highly expressed in basal breast cancer subtype (ERα-/PR-/Her2-) but not in the Her2 subtype (ERα-/PR-/Her2+) or luminal epithelial phenotype (ERα+/PR+). Only cytoplasmic staining is considered positive, whereas any nuclear staining is considered as background artifact. In normal skin, nestin is observed in endothelial cells and the bulge area of hair follicles.

质量


IVD

IVD

IVD

RUO

联系

Nestin Positive Control Slides, Product No. 388S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

制备说明

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其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律信息

Cell Marque is a trademark of sigma-aldrich Co. LLC

基本信息

NACRESNA.41

产品性质

质量水平500
100
生物来源mouse
偶联物unconjugated
抗体形式culture supernatant
antibody product typeprimary antibodies
克隆10C2, monoclonal
描述For In Vitro Diagnostic Use in Select Regions (See Chart)
形式buffered aqueous solution
species reactivityhuman
包装vial of 0.1 mL concentrate (388M-14)
vial of 0.5 mL concentrate (388M-15)
bottle of 1.0 mL predilute (388M-17)
vial of 1.0 mL concentrate (388M-16)
bottle of 7.0 mL predilute (388M-18)
manufacturer/tradenameCell Marque
technique(s)immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
同位素/亚型IgG1
控制tonsil
运输wet ice
储存温度2-8℃
可视化cytoplasmic

Sigma-Aldrich

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