产品说明
一般描述
Thrombomodulin is a transmembrane glycoprotein composed of 575 amino acids (molecular weight 75 kD with natural anticoagulant properties. It is normally expressed by a restricted number of cells, such as endothelial and mesothelial cells. In addition, synovial lining and syncytiotrophoblasts of human placenta also express thrombomodulin. Several immunohistochemical endothelial markers are currently available and anti-thrombomodulin serves as another such marker, staining blood and lymphatic channels consistently. Anti-thrombomodulin has demonstrated positivity in 100% of benign vascular tumors (pyogenic granuloma and hemangioma) and 94% of malignant vascular tumors (Kaposi′s sarcoma, angiosarcoma, and epithelioid hemangioendothelioma). Hence, anti-thrombomodulin serves as a sensitive marker for lymphatic endothelial cells and their tumors. There has also been recent interest in the use of anti-thrombomodulin as an immunohiostochemical marker for mesothelial cells and malignant mesotheliomas. Anti-thrombomodulin is immunoexpressed in a variety of other tumors including squamous cell carcinomas of the lung, synovial sarcoma, transitional cell carcinoma, renal cell carcinomas and thymomas.
质量
IVD | IVD | IVD | RUO |
联系
Thrombomodulin Positive Control Slides, Product No. 339S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
外形
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
制备说明
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其他说明
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
法律信息
Cell Marque is a trademark of sigma-aldrich Co. LLC
基本信息
NACRES | NA.41 |
产品性质
质量水平 | 500 100 |
生物来源 | mouse |
偶联物 | unconjugated |
抗体形式 | culture supernatant |
antibody product type | primary antibodies |
克隆 | 1009, monoclonal |
描述 | For In Vitro Diagnostic Use in Select Regions (See Chart) |
形式 | buffered aqueous solution |
species reactivity | human |
包装 | vial of 0.1 mL concentrate (339M-14) vial of 0.5 mL concentrate (339M-15) bottle of 1.0 mL predilute (339M-17) vial of 1.0 mL concentrate (339M-16) bottle of 7.0 mL predilute (339M-18) |
manufacturer/tradename | Cell Marque™ |
technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 |
同位素/亚型 | IgG1κ |
控制 | bladder, mesothelioma |
运输 | wet ice |
储存温度 | 2-8℃ |
可视化 | membranous |
Sigma-Aldrich