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位置:首页 > 品牌 > Sigma-Aldrich > MUC4 (8G7) Mouse Monoclonal Antibody

MUC4 (8G7) Mouse Monoclonal Antibody

品牌
Sigma-Aldrich
货号
406M-1
包装型号
规格纯度
参考价格
1995.44 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
MUC4 (8G7) Mouse Monoclonal Antibody
产品介绍:

产品说明

一般描述

Mucin 4 (MUC4) is a transmembranous glycoprotein. MUC4 is expressed in the cytoplasm of certain epithelial surfaces, such as colonic, breast, and lung epithelia. An abnormal expression of MUC4 has been reported in various carcinomas of the colon, pancreas, breast, and ovaries.MUC4 is highly expressed in the vast majority of human pancreatic neoplasms, such as intraductal papillary mucinous neoplasia of the pancreas, pancreatic intraepithelial neoplasms and pancreatic ductal adenocarcinoma; however, it is not detected in the normal pancreas or in chronic pancreatitis.MUC4 is not expressed in normal bile ducts, but it can be overexpressed in intrahepatic cholangiocarcinoma and bile duct cholangiocarcinoma. MUC4 overexpression has been reported in low-grade fibromyxoid sarcoma (LGFMS). In this study a large cohort of LGFMS, all with FUS gene rearrangement confirmed by FISH, showed cytoplasmic staining for MUC4, usually in a strong and diffuse manner. Similarly, strong, diffuse cytoplasmic staining for MUC4 was identified in 78% (32/41) of cases of sclerosing epithelioid fibrosarcoma. MUC4 expression is also detected in the glandular component of biphasic synovial sarcomas (90%). Focal staining, usually interpreted as only scattered cells, was also seen in a subset of ossifying fibromyxoid tumors (29%), epithelioid GISTs (20%) and myoepithelial carcinomas (10%); whereas all other epithelioid soft tissue tumors—including clear cell sarcoma, epithelioid sarcoma, epithelioid hemangiosarcoma, PEComa and melanoma—were negative. It should be noted that various carcinomas may express MUC4, and therefore additional keratins or lineage-specific markers may be needed to exclude this possibility in some cases.

质量


IVD

IVD

IVD

RUO

联系

MUC4 Positive Control Slides, Product No. 406S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

制备说明

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其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律信息

Cell Marque is a trademark of sigma-aldrich Co. LLC

基本信息

NACRESNA.41

产品性质

质量水平500
100
生物来源mouse
偶联物unconjugated
抗体形式culture supernatant
antibody product typeprimary antibodies
克隆8G7, monoclonal
描述For In Vitro Diagnostic Use in Select Regions (See Chart)
形式buffered aqueous solution
species reactivityhuman
包装vial of 0.1 mL concentrate (406M-14)
vial of 0.5 mL concentrate (406M-15)
bottle of 1.0 mL predilute (406M-17)
vial of 1.0 mL concentrate (406M-16)
bottle of 7.0 mL predilute (406M-18)
manufacturer/tradenameCell Marque
technique(s)immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:10-1:50
同位素/亚型IgG1κ
控制colon, colorectal adenocarcinoma, pancreatic ductal adenocarcinoma
运输wet ice
储存温度2-8℃
可视化cytoplasmic

Sigma-Aldrich

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