产品说明
一般描述
Citric acid monohydrate is an organic acid. Its molar enthalpy of solution in water has been reported to be ΔsolHm (298.15K, m = 0.0203molkg-1) = (29061 ± 123)Jmol-1
应用
Citric acid monohydrate may be used in the diltiazem hydrochloride (drug) and melt extruded Eudragit RS PO (polymer) formulations. It improves the solubility of drug in the polymer matrix. It may be used to prepare citrate buffer for use in the intravital microscopic studies of adhesion and aggregation of platelets.
基本信息
| 线性分子式 | HOC(COOH)(CH2COOH)2 · H2O |
| 分子量 | 210.14 |
| Beilstein | 4018641 |
| EC 号 | 201-069-1 |
| MDL编号 | MFCD00149972 |
| PubChem化学物质编号 | 57648219 |
| NACRES | NA.21 |
产品性质
| 质量水平 | 200 |
| 等级 | puriss. |
| 测定 | 99.5-100.5% (based on anhydrous substance) |
| 形式 | grit |
| 质量 | meets analytical specification of Ph. Eur., BP, USP, E330 |
| 杂质 | residual solvents, complies ≤0.0005% heavy metals (as Pb) 7.5-8.8% water (Karl Fischer) |
| 灼烧残渣 | ≤0.05% (as SO4) |
| pKa | (1) 3.13, (2) 4.76, (3) 6.4 |
| 痕量阴离子 | chloride (Cl-): ≤50 mg/kg oxalate (as oxalic acid): ≤100 mg/kg sulfate (SO42-): ≤100 mg/kg |
| 痕量阳离子 | As: ≤1 mg/kg Ca: ≤200 mg/kg Cu: ≤10 mg/kg Fe: ≤10 mg/kg Hg: ≤1 mg/kg Pb: ≤1 mg/kg Zn: ≤10 mg/kg |
| 适用性 | complies for appearance of solution complies for identity (IR) complies for reaction against H2SO4 |
| SMILES string | OC(CC(O)(C(O)=O)CC(O)=O)=O.O |
| InChI | 1S/C6H8O7.H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);1H2 |
| InChI key | YASYEJJMZJALEJ-UHFFFAOYSA-N |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H319 |
| 预防措施声明 | P305 + P351 + P338 |
| 危险分类 | Eye Irrit. 2 |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 1 |
| 闪点(F) | 345.0 °F |
| 闪点(C) | 173.9 ℃ |
| 个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
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