Monoclonal Anti-DCN antibody produced in mouse

产品说明

一般描述

Decorin (DCN) protein is encoded by the gene mapped to human chromosome 12q21.33. DCN is an extracellular matrix protein with leucine-rich repeats. The protein belongs to the small leucine-rich proteoglycan (SLRP) gene family.

免疫原

DCN (AAH05322, 1 a.a. ~ 359 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRSAIQLGNYK

生化/生理作用

Decorin (DCN) acts as a structural and signaling molecule and is involved in extracellular matrix assembly. It is implicated in the regulation of fibrogenesis and inflammation. DCN exhibits antimetastatic and antiangiogenic activities by inducing cell cycle arrest and apoptosis. It is used as a marker to detect the prognosis of various types of cancers such as breast, bladder, and lung cancer. Mutation in the DCN gene is associated with the development of posterior amorphous corneal dystrophy (PACD).

外形

Solution in phosphate buffered saline, pH 7.4

法律信息

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Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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