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Monoclonal Anti-HUS1 antibody produced in mouse

品牌
Sigma-Aldrich
货号
WH0003364M1
规格纯度
clone 2B12, purified immunoglobulin, buffered aqueous solution
参考价格
4888.5 *本价格含增值税费
促销
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数量
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产品名称:
Monoclonal Anti-HUS1 antibody produced in mouse
Anti-HUS1 checkpoint homolog (S. pombe)
产品介绍:

产品说明

一般描述

The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. (provided by RefSeq)

免疫原

HUS1 (AAH07013, 1 a.a. ~ 280 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MKFRAKIVDGACLNHFTRISNMIAKLAKTCTLRISPDKLNFILCDKLANGGVSMWCELEQENFFNEFQMEGVSAENNEIYLELTSENLSRALKTAQNARALKIKLTNKHFPCLTVSVELLSMSSSSRIVTHDIPIKVIPRKLWKDLQEPVVPDPDVSIYLPVLKTMKSVVEKMKNISNHLVIEANLDGELNLKIETELVCVTTHFKDLGNPPLASESTHEDRNVEHMAEVHIDIRKLLQFLAGQQVNPTKALCNIVNNKMVHFDLLHEDVSLQYFIPALS

外形

Solution in phosphate buffered saline, pH 7.4

法律信息

GenBank is a registered trademark of United States Department of Health and Human Services

基本信息

MDL编号MFCD08705464

产品性质

质量水平100
生物来源mouse
偶联物unconjugated
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆2B12, monoclonal
形式buffered aqueous solution
species reactivityhuman
technique(s)immunoprecipitation (IP): suitable
indirect ELISA: suitable
同位素/亚型IgG2aκ
GenBank® accession no.BC007013
UniProt登记号O60921
运输dry ice
储存温度−20℃
Gene Informationhuman ... HUS1(3364)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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