Monoclonal Anti-IGFBP1 antibody produced in mouse

产品说明

一般描述

Insulin-like growth factor binding protein 1 (IGFBP1) is a ~30 kDa secretory protein. It is formed mostly in the liver and kidney. IGFBP1 is a member of the IGFBPs family. This gene is located on human chromosome 7p12.
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. (provided by RefSeq)

免疫原

IGFBP1 (NP_000587, 160 a.a. ~ 259 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
GSKALHVTNIKKWKEPCRIELYRVVESLAKAQETSGEEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKRIPGSPEIRGDPNCQIYFNVQN

生化/生理作用

Insulin-like growth factor binding protein 1 (IGFBP1) participates in the modulation of fetal growth through the insulin-like growth factor axis. Due to its high-affinity binding, IGFBP1 also controls the IGF bioactivity. It has the capability to bind and regulate the bioavailability of circulating insulin-like growth factors (IGFs).

外形

Solution in phosphate buffered saline, pH 7.4

法律信息

GenBank is a registered trademark of United States Department of Health and Human Services

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

产品性质

安全信息