Monoclonal Anti-GCN5L2 antibody produced in mouse

产品说明

一般描述

General control of amino acid synthesis protein 5-like2 (GCN5L2) also known as KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM]GCN5L2 gene is located on human chromosome 17q21.2. This protein is expressed in ovaries.

免疫原

GCN5L2 (AAH32743, 738 a.a. ~ 837 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
KNLLAQIKSHPSAWPFMEPVKKSEAPDYYEVIRFPIDLKTMTERLRSRYYVTRKLFVADLQRVIANCREYNPPDSEYCRCASALEKFFYFKLKEGGLIDK

生化/生理作用

General control of amino acid synthesis protein 5-like2 (GCN5L2) regulates periodontitis through acetylation of dickkopf-related protein 1 (DKK1). It regulates early region 1A (E1A) dependant transactivation of human adenovirus. The protein modulates osteogenic differentiation of mesenchymal stem cells by blocking NF-κB (nuclear factor-κB) signalling pathway. GCN5 interacts with (origin recognition complex subunit 5) Orc5 and improves the chromatin-opening function of Orc5.

外形

Solution in phosphate buffered saline, pH 7.4

法律信息

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Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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