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NFF-2-Calbiochem

品牌
Sigma-Aldrich
货号
480450
规格纯度
A quenched fluorescence substrate for MMPs.
参考价格
3203.64 *本价格含增值税费
促销
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数量
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产品名称:
NFF-2-Calbiochem
MCA-RPKPYANvaWMK(DNP)-NH2
产品介绍:

产品说明

一般描述

A quenched fluorescent substrate for MMPs (excitation maximum: ~325 nm; emission maximum: ~393 nm). MMP-3 (stromelysin-1) hydrolyzes this substrate (kcat/Km = 59,400 M-1s-1) at a rate 60X faster than hydrolysis by MMP-1 (interstitial collagenase). NFF-2 shows little discrimination between MMP-3, MMP-2 (gelatinase-A; kcat/Km = 54,000 M-1s-1), and MMP-9 (gelatinase-B; kcat/Km = 55,300 M-1s-1).
A quenched fluorescence substrate for MMPs. MMP-3 (stromelysin-1) hydrolyzes this substrate (kcat/Km = 5.9 x 104 M-1sec-1) at a rate 60 times faster than the hydrolysis by MMP-1 (interstitial collagenase). NFF-2 shows little discrimination between MMP-3, MMP-2 (gelatinase-A; kcat/Km = 5 x 104 M-1s-1), and MMP-9 (gelatinase-B; kcat/Km = 5.5 x 104 M-1s-1).

包装

1 mg in Plastic ampoule

生化/生理作用

kcat/Km = 5.9 x 104 M-1sec-1 as substrates for MMP-3 (stromelysin-1)
Product does not compete with ATP.
Primary Target
Matrix Metalloproteinases (MMPs)
Reversible: no
Cell permeable: no

警告

Toxicity: Standard Handling (A)

序列

MCA-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(DNP)-NH₂ (DNP = 2,4-dinitrophenyl; Nva = L-norvaline)

外形

Supplied as a trifluoroacetate salt.

重悬

Following initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Nagase, H., et al. 1994. J. Biol. Chem. 269, 20952.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C79H105N19O19S
分子量1656.86

产品性质

质量水平100
测定≥98% (HPLC)
形式lyophilized solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
desiccated
protect from light
颜色 yellow
溶解性DMSO: 5 mg/mL
荧光λex ~325  nm
λem ~393 nm
运输ambient
储存温度−20℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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