Sodium Stibogluconate-CAS 16037-91-5-Calbiochem

产品名称：

16037-91-5
Sodium Stibogluconate-CAS 16037-91-5-Calbiochem
SSG, Antimony Sodium Gluconate, NaSb^v, PTP Inhibitor XXIV, SHP1 Inhibitor IV

产品介绍：

产品说明

一般描述

A pentavalent antimony compound that forms a stable complex with and irreversibly inhibits Src homology protein tyrosine phosphatase (SHP-1) (99% inhibition at 11 µM). Also inhibits SHP-2 and PTP1B at an ~10-fold higher concentration (~110 µM). Does not inhibit the dual specificity protein tyrosine phosphatase (PTPase) or mitogen-activated protein kinase phosphatase-1 (MKP-1). Reported to induce general protein tyrosine phosphorylation and enhance IL-3-induced protein tyrosine phosphorylation of Jak2 and Stat5 in Baf3 cells. Also reported to augment IL-3-induced proliferation in Baf3 cells (EC_max = 44 µM) and GM-CSF-induced proliferation in TF-1 cells (EC_max = 55 µM). Exhibits anti-leishmanial effects.
A pentavalent antimony compound that irreversibly inhibits protein tyrosine phosphatase (PTPase) activity, including Src homology PTPase-1 (SHP-1) (99% inhibition at ~11 µM) by forming a stable complex. At higher concentrations (~110 µM), it inhibits SHP-2 and PTP1B activities.

包装

1 g in Plastic ampoule
Packaged under inert gas

生化/生理作用

Target IC₅₀: ~11 µM causing 99% inhibition of protein tyrosine phosphatase (PTPase) activity, including Src homology PTPase-1 (SHP-1)
Product does not compete with ATP.
Reversible: yes
Primary Target
PTPase activity, including Src homology PTPase-1 (SHP-1)
Cell permeable: no

警告

Toxicity: Standard Handling (A)

制备说明

Heating to 75°C with constant stirring or constant stirring overnight at room temperature may be required for complete solubilization.

重悬

Unstable in solution; reconstitute just prior to use.

其他说明

Wortmann, G., et al. 2002. Clin. Infect. Dis.35, 261.
Pathak, M.K. and Yi, T. 2001. J. Immunol.167, 3391.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₂H₁₇O₁₇Sb₂ · 3Na · 9H₂O
分子量	907.88

产品性质

质量水平	100
测定	≥90% dry basis (≥30% Sb content, titration)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze desiccated protect from light
颜色	white
溶解性	water: 1 mg/mL
运输	ambient
储存温度	2-8℃
InChI	1S/2C6H10O7.3Na.9H2O.3O.2Sb/c27-1-2(8)3(9)4(10)5(11)6(12)13;;;;;;;;;;;;;;;;;/h22-5,7-8,10H,1H2,(H,12,13);;;;91H2;;;;;/q2-2;3+1;;;;;;;;;;;;;2+2/p-2/t2*2-,3-,4+,5-;;;;;;;;;;;;;;;;;/m11................./s1
InChI key	CUEDNFKBTFCOSV-UZVLBLASSA-L

安全信息

象形图
警示用语：	Warning
危险声明	H302 + H332 - H411
预防措施声明	P261 - P264 - P270 - P273 - P301 + P312 - P304 + P340 + P312
危险分类	Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable