CA-074-Calbiochem

品牌

Sigma-Aldrich

货号

205530

包装型号

1 MG, CA-074, also referenced under CAS 134448-10-5, modulates the biological activity of cathepsin B. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

规格纯度

CA-074, also referenced under CAS 134448-10-5, modulates the biological activity of cathepsin B. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

参考价格

3352.28 元 *本价格含增值税费

促销

数量

产品名称：

CA-074-Calbiochem
Cathepsin B Inhibitor III, [L-3- trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline

产品介绍：

产品说明

一般描述

A potent, irreversible inhibitor of Cathepsin B in vivo and in vitro (IC₅₀ = 2.24 nM for rat liver cathepsin B).
An epoxysuccinyl peptide that acts as a potent, irreversible, and specific inhibitor of cathepsin B (IC₅₀ = 2.24 nM for rat liver cathepsin B). Reduces ischemia-induced neuronal death. Exhibits lower membrane permeability when compared to CA-074 Me (Cat. No. 205531).

包装

1 mg in Plastic ampoule

生化/生理作用

Target IC₅₀: 2.24 nM for rat liver cathepsin B
Primary Target
cathepsin B
Product does not compete with ATP.
Reversible: no
Cell permeable: no

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Chan, V.J., et al. 1999. Biochem. J. 340, 113.
Tsuchiya, K., et al. 1999. Exp. Neurol. 155, 187.
Yamamoto, A., et al. 1997. J. Biochem.121, 974.
Inubushi, T., et al. 1994. J. Biochem. 116, 282.
Murata, M., et al. 1991. FEBS Lett. 280, 307.
Towatari, T., et al. 1991. FEBS Lett. 280, 311.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₈H₂₉N₃O₆
分子量	383.44

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze
颜色	colorless to white
溶解性	DMSO: 10 mg/mL
运输	ambient
储存温度	−20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3