产品说明

一般描述

A potent, cell-permeable and irreversible inhibitor of calpain II (k₂ = 28,900 M^-1s^-1). Also acts as an inhibitor of cathepsin L (k₂ = 680,000 M^-1s^-1).
A potent, cell-permeable, and irreversible inhibitor of calpain II (k₂ = 28,900 M^-1s^-1). Also acts as an inhibitor of cathepsin L (k₂ = 680,000 M^-1s^-1).

包装

1 mg in Plastic ampoule

生化/生理作用

Product does not compete with ATP.
Cell permeable: yes
k₂ = 28,900 M⁻¹s⁻¹ in the inhibition of calpain II; k2 = 680,000 M⁻¹s⁻¹ in the inhibition of cathepsin L
Reversible: no
Primary Target
calpain 2

警告

Toxicity: Standard Handling (A)

序列

Z-Leu-Leu-Tyr-CH₂F

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

分析说明

single spot by TLC

其他说明

Dutt, P., et al. 1998. FEBS Lett. 436, 367.
Angliker, H., et al. 1992. J. Med. Chem. 35, 216.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

产品性质

安全信息