Cathepsin K Inhibitor III-Calbiochem

产品说明

一般描述

A cell-permeable, potent, selective, reversible inhibitor of cathepsin K (K_i,app = 9.7 nM). At higher concentrations also inhibits the activities of cathepsin L, cathepsin B, and papain (K_i,app = 120 nM, 5.1 mM, and 2.3 µM, respectively). Reported to completely block cathepsin K activity in primary human synovial fibroblast cultures at a concentration of 1 µM.
A cell-permeable peptidyl bis-carbohydrazide compound that acts as a potent, selective, and reversible inhibitor of cathepsin K (K_i,app = 9.7 nM). At higher concentrations, also inhibits the activities of cathepsin L, cathepsin B, and papain (K_i,app = 120 nM, 5.1 µM, and 2.3 µM, respectively). Completely blocks cathepsin K activity in primary human synovial fibroblast cultures at 1 µM.

包装

1 mg in Glass bottle
Packaged under inert gas

生化/生理作用

Product does not compete with ATP.
Reversible: yes
Cell permeable: yes
Target K_i: 9.7 nM against cathepsin K
Primary Target
Cathepsin K

警告

Toxicity: Standard Handling (A)

序列

H-Phe-Leu-NHNH-CO-NHNH-Leu-Z

外形

Supplied as a trifluoroacetate salt.

重悬

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Wang, D., et al. 2002. Biochemistry41, 8849.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

产品性质

安全信息