产品说明
一般描述
A 14-amino acid peptide corresponding to the active IκB phosphorylation recognition sequence fused to the hydrophobic region of the fibroblast growth factor signal peptide to aid in cellular delivery. Specifically inhibits LPS-induced IκB degradation by IκB kinases (IKK) in RAW 264.7 cells (<50 µg/ml) and prevents NF-κB activation. Supplied as a trifluoroacetate salt.
A 14-amino acid peptide corresponding to the active IκB phosphorylation recognition sequence, linked to the hydrophobic region of the fibroblast growth factor signal peptide to aid in cellular delivery. Specifically inhibits LPS-induced IκB degradation by IkB kinases (IKK) in RAW 264.7 cells (<50 μg/ml) and prevents NF-κB activation.
包装
1 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Primary Target
LPS-induced IκB degradation by IKK in RAW 264.7 cells
Product does not compete with ATP.
Reversible: no
Target IC50: <50 µg/ml for inhibiting LPS-induced IκB degradation by IκB kinases (IKK) in RAW 264.7 cells and prevents NF-κB activation
Cell permeable: no
警告
Toxicity: Standard Handling (A)
序列
Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Asp-Arg-His-Asp-Ser-Gly-Leu-Asp-Ser-Met-Lys-Asp-Glu-NH₂
外形
Supplied as a trifluoroacetate salt.
重悬
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Swaroop, N., et al. 2001. Pharm. Res.18, 1631.
Traenckner, E.B., et al. 1995. EMBO. J.14, 2876.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
经验(实验)分子式 | C138H229N37O45S |
分子量 | 3158.58 |
产品性质
质量水平 | 100 |
测定 | ≥95% (HPLC) |
形式 | lyophilized |
manufacturer/tradename | Calbiochem® |
储存条件 | OK to freeze desiccated (hygroscopic) protect from light |
溶解性 | PBS, pH 7.4: 1 mg/mL |
运输 | wet ice |
储存温度 | −20℃ |
安全信息
储存分类代码 | 11 - Combustible Solids |
WGK | WGK 1 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich