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InSolution Gö 6976-CAS 136194-77-9-Calbiochem

品牌
Sigma-Aldrich
CAS
136194-77-9
货号
365253
包装型号
规格纯度
参考价格
3124.36 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
136194-77-9
InSolution Gö 6976-CAS 136194-77-9-Calbiochem
Go 6976, Solution, 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole
产品介绍:

产品说明

一般描述

Inhibitor of protein kinase C (PKC; IC50 = 7.9 nM for rat brain). Selectively inhibits Ca2+-dependent PKCα-isozyme (IC50 = 2.3 nM) and PKCβI (IC50 = 6.2 nM). Does not affect the kinase activity of the Ca2+-independent PKC δ-, ε-, and ζ-isoenzymes even at micromolar levels. A potent antagonist of HIV-1 induction.

包装

1 ml in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Product competes with ATP.
Target IC50: 7.9 nM, 2.3 nM, and 6.2 nM, for rat brain PKC, Ca2+-dependent PKC α-isozyme, and PKCβI, respectively
Reversible: yes
Primary Target
PKC

警告

Toxicity: Irritant (B)

外形

A 500 µg/ml solution of Gö 6976 (Cat. No. 365250) in anhydrous DMSO.

重悬

Following initial thaw, aliquot and freeze (-20°C).

其他说明

Gschwendt, M., et al. 1996. FEBS Lett.392, 77.
Wenzel-Seifert, K., et al. 1994. Biochem. Biophys. Res. Commun.200, 1536.
Martiny-Baron, G., et al. 1993. J. Biol. Chem.268, 9194.
Qatsha, K.A., et al. 1993. Proc. Natl. Acad. Sci. USA90, 674.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C24H18N4O
分子量378.43
MDL编号MFCD00236434

产品性质

质量水平100
测定≥95% (HPLC)
形式liquid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
溶解性DMSO: 5 mg/mL
运输wet ice
储存温度−20℃
InChI1S/C24H18N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,12-13H2,1H3,(H,26,29)
InChI keyVWVYILCFSYNJHF-UHFFFAOYSA-N

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)188.6 °F - (Dimethylsulfoxide)
闪点(C)87 ℃ - (Dimethylsulfoxide)

Sigma-Aldrich

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