RSK Inhibitor, SL0101

产品说明

一般描述

A cell-permeable Kaempferol (Cat. No. 420345) glycoside that targets the the N-terminal kinase domain of p90 ribosomal S6 kinase and inhibits RSK kinase activity (IC₅₀ = 89 nM with 10 µM ATP) in a selective, reversible, and ATP-competitive (K_i = 1 µM) manner. Shown to inhibit the proliferation of MCF-7, but not the normal breast cell line MCF-10A, and specifically block PDB-induced cellular phosphorylation of RSK substrate p140, but not that of RSK or RSK upstream kinases even at concentrations as high as 100 µM. Also available as a 10 mM solution in DMSO (Cat. No. 559292).
A cell-permeable Kaempferol (Cat. No. 420345) glycoside that targets the the N-terminal kinase domain of p90 ribosomal S6 kinase and inhibits RSK kinase activity (IC₅₀ = 89 nM with 10 µM ATP) in a selective, reversible, and ATP-competitive (K_i = 1 µM) manner. Shown to inhibit the proliferation of MCF-7, but not the normal breast cell line MCF-10A, and specifically block PDB-induced cellular phosphorylation of RSK substrate p140, but not that of RSK or RSK upstream kinases even at concentrations as high as 100 µM.

包装

1 mg in Plastic ampoule
Packaged under inert gas

警告

Toxicity: Regulatory Review (Z)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Smith, J.A., et al. 2007. Bioorg. Med. Chem.15, 5018.
Smith, J.A., et al. 2006. Bioorg. Med. Chem.14, 6043.
Xu, Y.M., et al. 2006. Bioorg. Med. Chem.14, 3974.
Maloney, D.J. and Hecht, S.M., 2005. Org. Lett.7, 1097.
Smith, J.A., et al. 2005. Cancer Res.65, 1027.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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