您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 品牌 > Sigma-Aldrich > TNF-α Antagonist-Calbiochem

TNF-α Antagonist-Calbiochem

品牌
Sigma-Aldrich
货号
654255
规格纯度
The TNF-α Antagonist controls the biological activity of TNF-α.
参考价格
4224.61 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
TNF-α Antagonist-Calbiochem
TNF Antagonist, WP9QY, Tumor Necrosis Factor Antagonist, TNF-TNFR Signaling Inhibitor I
产品介绍:

产品说明

一般描述

An exocyclic peptidomimetic that acts as a TNF-α antagonist (IC50 = 5 µM) in binding assay. Blocks TNF-α-mediated apoptosis in mouse L929 cells. Exhibits about twofold higher activity than other known WP5 binding site derived mimetics. Designation WP9QY arises from the binding to the WP9 binding site of the TNF-β/TNF-receptor(I) complex as template, and the introduction of amino acids, Gln and Tyr.
An exocyclic peptidomimetic that acts as a TNF-α antagonist (IC50 = 5 µM) in the binding assay. Blocks TNF-α-mediated apoptosis in mouse L929 cells. The designation WP9QY arises from the binding to the site observed in the TNF-β/TNF-receptor (I) complex as template, and the introduction of amino acids Glu and Tyr.

包装

1 mg in Plastic ampoule

生化/生理作用

Product does not compete with ATP.
Reversible: no
Target IC50: 5 µM as TNF-α antagonist
Cell permeable: no

警告

Toxicity: Standard Handling (A)

序列

H-Tyr-Cys-Trp-Ser-Gln-Tyr-Leu-Cys-Tyr-OH (disulfide bond: 2 → 8)

其他说明

Takasaki, W., et al. 1997. Nat. Biotechnol. 15, 1266.

法律信息

Sold under license of U.S. Patent 6,265,535.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C58H71N11O15S2
分子量1226.38

产品性质

质量水平100
测定≥95% (HPLC)
形式lyophilized
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
desiccated (hygroscopic)
溶解性water: 1 mg/mL
5% acetic acid: 5 mg/mL
运输ambient
储存温度−20℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品