产品说明
Amino Acid Sequence
NAc-Asp-Glu-Val-Asp-AFC
生化/生理作用
A fluorogenic substrate for caspase 3, a protease that is rapidly activated when cells are exposed to apoptotic conditions and that cleaves poly(ADP-ribose) polymerase. The 7-amido-4-trifluoromethylcoumarin derivative has better membrane permeability than the 7-amido-4-methylcoumarin derivative (A1086).
包装
Bottomless glass bottle. Contents are inside inserted fused cone.
基本信息
| 经验(实验)分子式 | C30H34F3N5O13 |
| 分子量 | 729.61 |
| MDL编号 | MFCD01310970 |
| PubChem化学物质编号 | 329770614 |
| NACRES | NA.32 |
产品性质
| 质量水平 | 200 |
| 测定 | ≥90% (HPLC) |
| 形式 | powder |
| 颜色 | white |
| 溶解性 | H2O: 1 mg/mL |
| 储存温度 | −20℃ |
| SMILES string | CC(C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H](CC(O)=O)C(=O)Nc1ccc2c(OC(=O)C=C2C(F)(F)F)c1 |
| InChI | 1S/C30H34F3N5O13/c1-12(2)25(38-26(47)17(6-7-21(40)41)36-28(49)18(10-22(42)43)34-13(3)39)29(50)37-19(11-23(44)45)27(48)35-14-4-5-15-16(30(31,32)33)9-24(46)51-20(15)8-14/h4-5,8-9,12,17-19,25H,6-7,10-11H2,1-3H3,(H,34,39)(H,35,48)(H,36,49)(H,37,50)(H,38,47)(H,40,41)(H,42,43)(H,44,45)/t17-,18-,19-,25-/m0/s1 |
| InChI key | GZDRODOYEFEHGG-NUDCOPPTSA-N |
| Gene Information | human ... CASP3(836) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
Sigma-Aldrich
m.cnreagent.com
