产品说明
一般描述
α1-Antichymotrypsin (α1-ACT) is also known as serpin peptidase inhibitor, clade A member 3 (SERPINA3). It is a 68 kDa serine protease inhibitor, secreted by the liver. It belongs to the serpin superfamily of protease inhibitors. SERPINA3 is located on human chromosome 14q32.1.
应用
α1-Antichymotrypsin from human plasma has been used as a component in yeast extract peptone dextrose broth (YEPD) for biofilm dispersion assays.
生化/生理作用
α1-Antichymotrypsin (α1-ACT) can block the functions of various serine proteases like chymotrypsin and cathepsin G. It serves as a potential therapeutic target of endometrial carcinoma (EC).
Specific inhibitor of chymotrypsin-like serine proteases. Promotes amyloid-β polymerization in vitro and in vivo. Levels in plasma and cerebrospinal fluid have been found to correlate with progression of dementia in Alzheimer′s patients and induce phosphorylation of tau protein in neurons.
包装
Package size based on protein content.
外形
Lyophilized powder containing Tris buffer salt and NaCl.
基本信息
| MDL编号 | MFCD00162030 |
产品性质
| 质量水平 | 200 |
| 生物来源 | human plasma |
| 测定 | ≥92.5% (SDS-PAGE) |
| 形式 | lyophilized powder |
| 分子量 | 55-66 kDa |
| technique(s) | microbiological culture: suitable |
| UniProt登记号 | P01011 |
| 储存温度 | −20℃ |
| Gene Information | human ... SERPINA3(12) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
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