GF 109203X

产品名称：

133052-90-1
GF 109203X
3-(N-[Dimethylamino]propyl-3-indolyl)-4-(3-indolyl)maleimide
Bisindolylmaleimide I
3-[1-[3-(Dimethylamino)propyl]1H-indol-3-yl]-4-(1Hindol-3-yl)1H-pyrrole-2,5dione

产品介绍：

产品说明

应用

GF 109203X has been used as a protein kinase C inhibitor in HUVECs (human umbilical vein endothelial cells), angiotensinogen gene knockout (AGT KO) mice, and in granulosa cell cultures of female rats.

生化/生理作用

A potent and selective competitive inhibitor of protein kinase C (PKC) and of glycogen synthase kinase-3 (GSK-3). Inhibits parathyroid hormone-induced Ca²⁺ resorption from isolated bone tissue, Staurosporine, another protein kinase inhibitor, actually enhanced Ca²⁺ resorption elicited by a number of agents, but GF109203X counteracted that enhancement.
A potent and selective competitive inhibitor of protein kinase C (PKC) and of glycogen synthase kinase-3 (GSK-3). In certain cells, inhibition of PKC leads to an increase in autophagy. For PKC inhibition, typically used at a concentration of 0.1-10 μM.

数量

For PKC inhibition, typically used at a concentration of 0.1-10 μM.

基本信息

经验(实验)分子式	C₂₅H₂₄N₄O₂
分子量	412.48
MDL编号	MFCD00236428
PubChem化学物质编号	329799908
NACRES	NA.77

产品性质

质量水平	100
生物来源	synthetic
测定	≥90% (HPLC)
溶解性	DMSO: soluble (~1 mg/ml)
储存温度	2-8℃
SMILES string	CN(C)CCCn1cc(C2=C(C(=O)NC2=O)c3c[nH]c4ccccc34)c5ccccc15
InChI	1S/C25H24N4O2/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31)
InChI key	QMGUOJYZJKLOLH-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H351
预防措施声明	P201 - P202 - P280 - P308 + P313 - P405 - P501
危险分类	Carc. 2
补充剂危害	EUH019
储存分类代码	11 - Combustible Solids
WGK	WGK 3