产品说明

应用

Microsomes from Liver, Pooled has been used:

• in the glucuronidation kinetics assay to test the effects of herbal extracts on glucuronidation process
• as a human liver microsomes (HLM) matrix for testing metabolic stability of talazoparib using liquid chromatography-tandem mass spectrometry (LC–MS/MS)
• to study the metabolization of enantiomeric peptide D3

Microsomes from liver have been used in a study to assess differences in enzymatic activities between normal rat livers and from liver after partial hepatectomy. They have also been used in a study to investigate the carbon monoxide-binding pigment in liver microsomes.

生化/生理作用

肝微粒体是来源于肝细胞内质网的亚细胞颗粒。这些微粒体是药物代谢酶(包括细胞色素 P-450)的丰富来源。不同来源的微粒体池有助于研究外源代谢和药物相互作用。
N-glucuronidation of various 1-substituted imidazoles was found to occur in human liver microsomes.

基本信息

NACRES

NA.54

产品性质

质量水平	200
生物来源	human male
测定	~10 mg per vial
形式	liquid
运输	dry ice
储存温度	−70℃

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable