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Anti-Interleukin-4 antibody produced in goat

品牌
Sigma-Aldrich
货号
I7526
规格纯度
affinity isolated antibody, lyophilized powder
参考价格
4330.86 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-Interleukin-4 antibody produced in goat
Anti-IL-4
产品介绍:

产品说明

一般描述

Interleukin-4 (IL-4) is a T cell derived chemokine that stimulates the Th2 mediated immune response and proliferation of B cells. The effects of IL-4 are mediated by two types of receptors, type I receptor consisting of IL-4Rα and common γ chain and type II receptor composed of IL-4Rα and IL-13Rα1. The signaling stimulated by IL-4 leads to activation of JAK/STAT6 and IRS-mediated PI3K/Akt pathway. Through these pathways, IL-4 is responsible for endocytic activity of macrophages, chemotaxis of leukocytes in response to inflammation, angiogenesis and regulation of nitric oxide metabolism in macrophages. Anti-tumor effects of IL-4 have been reported in cancers of breast, liver and renal cells. Anti-Interleukin-4 specifically recognizes human interleukin-4. The antibody shows no cross reactivity with rmIL-4 and rrIL-4.

特异性

The antibody will neutralize the biological activity of recombinant human IL-4, but not recombinant mouse IL-4.

免疫原

recombinant human IL-4.

应用

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Anti-Interleukin-4 antibody may be used for immunoblotting at a working concentration of 0.1-0.2 μg/ml. For ELISA, a working concentration of 0.5-1.0 μg/ml is recommended. The antibody may be used for immunohistochemistry of cultured cells or tissue sections at a working antibody concentration of 0.5-5 μg/ml. The antibody is suitable for neutralization assay; ND50 is 0.02-0.1 μg/ml. Anti-IL-4 antibody was used for immunohistochemistry and ELISA using cervicovaginal tissue sections and cervicovaginal extracts of Belgium white rabbits.

外形

Lyophilized from 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD00212213
NACRESNA.41

产品性质

质量水平100
生物来源goat
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式lyophilized powder
species reactivityhuman
technique(s)indirect ELISA: suitable
neutralization: suitable
western blot: suitable
UniProt登记号P05112
储存温度−20℃
Gene Informationhuman ... IL4(3565)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)

Sigma-Aldrich

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