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位置:首页 > 品牌 > Sigma-Aldrich > Anti-phospho-c-Kit (SCFR) (pTyr730) antibody produced in rabbit

Anti-phospho-c-Kit (SCFR) (pTyr730) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
C6615
规格纯度
affinity isolated antibody, buffered aqueous solution
参考价格
4330.86 *本价格含增值税费
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数量
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产品名称:
Anti-phospho-c-Kit (SCFR) (pTyr730) antibody produced in rabbit
Anti-phospho-SCF Receptor (pTyr730)
产品介绍:

产品说明

一般描述

Mast cells play an important role in innate immunity or the response of the body to invading pathogens. The functions of mast cells are regulated by a number of surface receptors; c-Kit (Stem cell factor receptor, SCF R; CD117) being the most critical. The signalling triggered by c-Kit results in mast cell activation in response to antigens. The response involves tyrosine phosphorylation by specific tyrosine kinases that drive the downstream signalling process. The secondary pathways activated by c-Kit include Akt, mTOR, MAPK, Sos-Grb2 and c-Jun. Phosphorylation of tyrosine 730 is required for the binding of PLCγ leading to activation of various signalling pathways In addition to development of mast cells, c-Kit also regulates their subsequent maturation and homing to the residence sites. Constitutive activation by SCF R is implicated in myeloproliferative discorders, systemic mastocytosis and gastrointestinal stomal cell tumors
The antibody detects human c-Kit pTyr730. Mouse, rat and cow (100% homologous), dog (92% homologous), chicken (85%) are expected to react.

免疫原

synthetic phosphopeptide derived from the region of human c-Kit that contains tyrosine 730.

应用

Anti-phospho-c-Kit (SCFR) pTyr730 antibody may be used for immunoblotting at a working concentration of 0.1-1.0 μg/ml using M07e cells.

外形

Solution in Dulbecco′s phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, with 1.0 mg/mL BSA (IgG and protease free) and 0.05% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD06411871
NACRESNA.41

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
species reactivityrat, human, mouse
technique(s)western blot: 0.1-1.0 μg/mL using M07e cells
UniProt登记号P10721
运输dry ice
储存温度−20℃
Gene Informationhuman ... KIT(3815)
mouse ... Kit(16590)
rat ... Kit(64030)

Sigma-Aldrich

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