Anti-phospho-FAK (pTyr⁸⁶¹) antibody produced in rabbit

产品说明

一般描述

Focal adhesion kinase (FAK) is a cytoplasmic protein that belongs to non-receptor protein tyrosine kinase family. It has a critical role in regulation of cell differentiation, migration, adhesion and acceleration of the G1 to S phase transition in cell cycle. Anti-phospho-FAK (pTyr⁸⁶¹) antibody can be used in immunohistochemistry. Rabbit anti-phospho-FAK (pTyr⁸⁶¹) antibody reacts specifically with FAK (125kD) phosphorylated at tyrosine 861. This product can also react with FAK (pTyr⁸⁶¹) of mouse, chicken and human.
Focal adhesion kinase (FAK) is a non-receptor cytoplasmic protein tyrosine kinase. It is coded by the PTK2 (protein tyrosine kinase 2) gene that is located on human chromosome 8q24.3.

免疫原

synthetic phosphopeptide derived from the region of FAK that contains tyrosine 861.

应用

Anti-phospho-FAK (pTyr⁸⁶¹) antibody can be used in western blotting (diluted 1:1000).

生化/生理作用

Focal adhesion kinase (FAK) participates in cell signaling pathways that leads to cell proliferation, invasion, survival and metastasis. It is essential for normal embryonic development. This protein controls CSC (cancer stem cells) properties in breast, gastrointestinal and squamous cell carcinoma.

外形

Solution in Dulbecco′s phosphate buffered saline (without Mg²⁺ and Ca²⁺), pH 7.3, with 50% glycerol, 1.0 mg/ml BSA (IgG and protease free) and 0.05% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

产品性质

安全信息