Anti-phospho-MEK4 (pSer²⁵⁷/pThr²⁶¹) antibody produced in rabbit

产品说明

一般描述

Mitogen-Activated Protein Kinase Kinase 4 (MEK 4 or MKK4) is a 42 kDa member of a tyrosine/threonine protein kinase family that activates the c-Jun NH2-terminal kinases (JNK), which is part of the inflammation/stress signaling pathway. The mutation of the MEK 4 gene in some carcinomas indicates that it may also have a role as a tumor suppressor. Phosphorylation of MEK4 by MEKK1 on serine 257 and threonine 261 in the catalytic domain activates the protein and enables MEK 4 to phosphorylate JNK
This antibody specifically recognizes human MEK 4 double phosphorylated at serine 257 and threonine 261. Mouse and frog MEK 4 (100% homology) may cross react.

免疫原

synthetic MEK4-derived phosphopeptide that is phosphorylated at serine 257 and threonine 261.

应用

Anti-phospho-MEK4 (Tyr³⁹⁷) antibody may be used for detection by immunoblotting at a working concentration of 0.1-1.0 μg/mL.

外形

Solution in Dulbecco′s phosphate buffered saline (without Mg²⁺ and Ca²⁺), pH 7.3, with 1.0 mg/mL BSA (IgG and protease free) and 0.05% sodium azide.

基本信息

产品性质