Anti-phospho-TrkA (pTyr⁴⁹⁰) antibody produced in rabbit

产品说明

一般描述

TrkA belongs to the Trk proto-oncogene family and is expressed mainly in central and peripheral nervous systems. When TrkA binds to NGF, it autophosphorylates tyrosine residues like-Tyr⁴⁹⁰, Tyr⁶⁷⁴, Tyr⁶⁷⁵, Tyr⁷⁵¹, and Tyr⁷⁸⁵ and subsequently activates many downstream effector proteins. Defects in TrkA lead to congenital insensitivity to pain with anhidrosis. Anti-phospho-TrkA (pTyr⁴⁹⁰) antibody can be used in immunocytochemistry (1:100, using cultured cells). It is also useful in identifying endogenous levels of phosphorylated Tyr⁴⁹⁰ in TrkA, TrkB and TrkC. Rabbit anti- phospho-TrkA (pTyr⁴⁹⁰) antibody is reactive in mouse, human and rat.

免疫原

synthetic phosphopeptide Tyr⁴⁹⁰ corresponding to residues surrounding Tyr⁴⁹⁰ of human TrkA, conjugated to KLH. This sequence is highly conserved in TrkB and TrkC.

应用

Anti-phospho-TrkA (pTyr⁴⁹⁰) antibody can be used in immunoprecipitation, immunoblotting and immunohistochemistry. It may also be used in western blotting when diluted to ratio of 1:1000 for NGF-treated PC12 cells.

外形

Solution in 10 mM sodium HEPES, pH 7.5, and 150 mM sodium chloride containing 100 μg/ml bovine serum albumin and 50% glycerol.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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