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Anti-Serine/Threonine Protein Phosphatase 2C α/β antibody produced in rabbit

Anti-Serine/Threonine Protein Phosphatase 2C α/β antibody produced in rabbit

品牌
Sigma-Aldrich
货号
P8609
规格纯度
IgG fraction of antiserum, buffered aqueous solution
参考价格
4330.86 *本价格含增值税费
促销
服务
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数量
-+
产品名称:
Anti-Serine/Threonine Protein Phosphatase 2C α/β antibody produced in rabbit
产品介绍:

产品说明

一般描述

Among the post-translational modifications, phosphorylation is a vital regulatory mechanism of key proteins involved in specific pathways. Reverse phosphorylation has become recognized as the key process of regulation of gene expression, cellular proliferation, differentiation in Eukaryotes. Protein phosphatases, like kinases, are a class of enzymes that regulate protein phosphorylation. The serine/threonine phosphatases have been classified into four groups which include PP1, PP2A, PP2B (also termed calcineurin) and PP2C on the basis of differences in their biochemical properties. Protein phosphatases 2C (PP2Cs) are serine/threonine protein phosphatases primarily involved in stress responses. Two isoforms PP2C α and PP2Cβ are reported. Functionally, PP2C isoforms suppress TGF-β-activated kinase (TAK1), STAT3 and the nuclear factor κB pathway.
Anti-Serine/Threonine Protein Phosphatase 2C α/β specifically recognizes 44-46 kDa protein phosphatase 2C α?and β?isoforms.

免疫原

synthetic peptide corresponding to amino acids 23-37 of the protein phosphatase 2C α/β structural subunit.

应用

The recommended working dilution is 1:1000 to 1:5000 for immunoblotting using peroxidase conjugated goat anti-rabbit IgG and chemiluminescent detection. The recommended working dilution for immunoprecipitation is 1:1000 to 1:5000. The antibody is suitable for protein microarray.

外形

Solution in phosphate buffered saline containing 0.08% sodium azide

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD03455948
NACRESNA.44

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式IgG fraction of antiserum
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量antigen 44-46 kDa
species reactivitymouse, bovine, rabbit, human
technique(s)immunoprecipitation (IP): suitable
microarray: suitable
western blot: 1:500-1:1,000 using total rat brain homogenate
UniProt登记号P35813
运输dry ice
储存温度−20℃
Gene Informationhuman ... PPM1A(5494), PPM1B(5495)
mouse ... Ppp2ca(19052), Ppp2cb(19053)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKnwg
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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