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Chk2 Inhibitor II-CAS 516480-79-8-Calbiochem

品牌
Millipore
CAS
516480-79-8
货号
220486
规格纯度
Chk2 Inhibitor II, BML-277, CAS 516480-79-8 is a cell-permeable, potent, reversible, ATP-competitive inhibitor of Chk2 (IC50 = 15 nM).
参考价格
2096.01 *本价格含增值税费
促销
服务
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数量
-+
产品名称:
516480-79-8
Chk2 Inhibitor II-CAS 516480-79-8-Calbiochem
2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide
产品介绍:

产品说明

一般描述

A cell-permeable and reversible benzimidazolo compound that acts as a potent and ATP-competitive inhibitor of Chk2 with an IC50 of 15 nM and a Ki of 37 nM. Displays ~ 1,000-fold greater selectivity over Cdk1/B and CK1 (IC50 = 12 M and 17 M, respectively) and only weakly affects the activities of a panel of 31 kinases (<25% inhibition at 10 M), including Chk1. Shown to rescue both peripheral CD4+ and CD8+ T-cells from γ-irradiation-induced apoptosis with an EC50 of 3 M and 7.6 M, respectively. Also available as a 25 mM solution in DMSO (Cat. No. 220491).
A cell-permeable, potent, reversible and ATP-competitive inhibitor of Chk2 (checkpoint kinase 2; IC50 = 15 nM; Ki = 37 nM). Displays ~1,000-fold greater selectivity for Chk2 compared to Cdk1/cyclin B and CK1 (IC50 = 12 µM and 17 µM, respectively) and only weakly affects the activities of a panel of 31 kinases (<25% inhibition at 10 µM), including Chk1. Shown to rescue both peripheral CD4+ and CD8+ T-cells from γ-irradiation-induced apoptosis with an EC50 of 3 µM and 7.6 µM, respectively.

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Primary Target
Chk2
Ki = 37 nM inhibiting Chk2.EC50 = 3 µM and 7.6 µM in rescuing both peripheral CD4+ and CD8+ T-cells from γ-irradiation-induced apoptosis
Target Ki: 37 nM inhibiting Chk2
Reversible: yes
Cell permeable: yes
Product competes with ATP.

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Arienti, K. L., et al. 2005. J. Med. Chem.48, 1873.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C20H14ClN3O2
分子量363.80

产品性质

质量水平100
测定≥95% (HPLC)
形式solid
效能15 nM IC50
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色pale yellow
溶解性DMSO: 5 mg/mL
运输ambient
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3

Sigma-Aldrich

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