Monoclonal Anti-S1P₂, C-Terminal antibody produced in mouse

产品说明

免疫原

human EDG-5/S1P₂ unique C-terminal peptide.

应用

Monoclonal Anti-S1P₂, C-Terminal antibody produced in mouse is suitable for western blotting at a working dilution of 1:1000 (1μg/mL) using human T lymphoblasts, ovarian tumor cells, epithelial cells, estrogen receptor positive breast carcinoma cells, human spleen and rat spleen or lung.

生化/生理作用

Sphingosine-1-phosphate receptor 2 (S1PR2 or S1P2) is a human gene encodes a G protein-coupled receptor. It binds the lipid signaling molecule sphingosine 1-phosphate (S1P) and regulates vascular permeability along with S1P1. Activation of S1P2R in endothelial cells increases vascular permeability. It is a bioactive lysophospholipid capable of inducing a wide spectrum of biological responses. S1P acts as an intercellular mediator by interacting with the endothelial differentiation gene (EDG)/S1P family of G protein-coupled receptors. S1P2 receptor is involved in S1P-induced platelet aggregation and Rho kinase activation. Type 2 diabetes patient responds to S1P.

目标描述

EDG-5/S1P₂ belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-5/S1P₂ is sphingosine 1-phosphate, and is expressed in cardiovascular, central nervous system, gonadal, placental and leukocyte-containing tissue.

制备说明

Purified from in vitro cell culture supernatants using protein A.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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