产品说明

一般描述

The NF-κB transcription factors are presented inactive in the cytoplasm by inhibitor protein IκB. In response to stimuli such as UV light or inflammatory cytokines, phosphorylation and subsequent degradation of IκB, allows for nuclear translocation of NF-κ B where it functions as transcription factor. IκB is phosphorylated by a serine kinase, IκB kinase (IKK). The IKK consists of three subunits, IKKα and IKKβ are the catalytic, IKKγ is a regulatory subunit. IKKα and its upstream kinase, NIK are the key kinases in the activation of the alternate or the non-canonical NFκB pathway. IKKα has been reported to function independent of either IKKβ or IKKγ in activation of NF-κB. IKKα also shows functions other than activation of NF-κ B. It binds the promoters of estrogen-responsive genes, Cyclin D1 and c-myc
Anti-IKKα?detects IKKα?(85 kDa) and has no cross-reactivity with IKKβ?or IKKγ.

免疫原

synthetic peptide corresponding to amino acids 699-715 of human IκB Kinase α (IKK α) (C2). This sequence contains one amino acid substitution with the mouse sequence.

应用

Anti-IKK α subunit may be used for detection by immunoblotting at a recommended concentration of 1 μg/mL or 1:500 dilution using HeLa whole cell lysates.

外形

Solution in phosphate buffered saline containing 0.02% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

产品性质