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Anti-phospho-Tau (pSer199/202) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
T6819
规格纯度
affinity isolated antibody, buffered aqueous glycerol solution
参考价格
4731.57 *本价格含增值税费
促销
服务
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数量
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产品名称:
Anti-phospho-Tau (pSer199/202) antibody produced in rabbit
产品介绍:

产品说明

一般描述

Tau proteins are known as microtubule-associated phosphoprotein (MAP) and express mainly in neurons of central nervous system. It has a crucial role in tubulin polymerization and facilitates microtubules assembly and stability. The biological activity of tau proteins depends on degree of its phosphorylation. Anti-phospho-Tau (pSer199/202) antibody can be used in microarray and western blotting. It can also be used in immunoblotting. Rabbit anti- phospho-Tau (pSer199/202) antibody reacts specifically with human Tau (pSer199/202) (45-68 kD).
Tau (τ), also known as MAPT (microtubule associated protein tau), is encoded by the gene mapped to human chromosome 17q21.3. It is highly expressed in neurons, but is most prominent in axons.

免疫原

chemically synthesized phosphopeptide derived from the region of human tau that contains serine199 and serine202.

应用

Anti-phospho-Tau (pSer199/202) antibody (diluted 1:1000 in PBS containing 0.3% Triton X-100 and 0.5% BSA) can be used in immunocytochemistry for identification of protein aggregates. It can also be used as primary antibody (diluted 1: 3000) in immunohistochemistry.
Anti-phospho-Tau (pSer199/202) antibody produced in rabbit has been used in:

  • immunocytochemistry
  • immunohistochemistry
  • western blot

生化/生理作用

Tau (τ) plays an essential role in the assembly and maintenance of microtubule structure. Deletion of tau (τ) results in developmental delay and learning disability. The gene expression is associated with the development of Alzheimer′s disease (AD). Genetic variation in τ gene increases the risk of susceptibility to the sporadic tauopathies, progressive supranuclear palsy (PSP) and corticobasal degeneration.

外形

Solution in 100 μl Dulbecco′s phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 50% glycerol, containing 1.0 mg/ml BSA (IgG, protease free) and 0.05% sodium azide. The amount of antibody is sufficient for 10 immunoblots.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD03455771
NACRESNA.41

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous glycerol solution
species reactivitymouse, rat, human
technique(s)microarray: suitable
western blot: suitable
UniProt登记号P10636
运输wet ice
储存温度−20℃
Gene Informationhuman ... MAPT(4137)
mouse ... Mapt(17762)
rat ... Mapt(29477)

安全信息

象形图GHS07
警示用语:Warning
危险声明H315 - H319
预防措施声明P305 + P351 + P338
危险分类Eye Irrit. 2 - Skin Irrit. 2
储存分类代码10 - Combustible liquids
WGKWGK 3
闪点(F)320.0 °F - closed cup
闪点(C)160 ℃ - closed cup

Sigma-Aldrich

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