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Caspase-3/7 Inhibitor II-CAS 775289-20-8-Calbiochem

品牌
Sigma-Aldrich
CAS
775289-20-8
货号
218832
规格纯度
The Caspase-3/7 Inhibitor II, also referenced under CAS 775289-20-8, controls the biological activity of Caspase-3/7. This small molecule/inhibitor is primarily used for Cancer applications.
参考价格
2427.06 *本价格含增值税费
促销
服务
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数量
-+
产品名称:
775289-20-8
Caspase-3/7 Inhibitor II-CAS 775289-20-8-Calbiochem
Ac-DNLD-CHO
产品介绍:

产品说明

一般描述

A tetrapeptidyl aldehyde that acts as a potent, reversible and active site binding inhibitor of caspases-3 and -7 (IC50 = 3.2 nM and 22.6 nM, respectively) and displays ~100-fold greater selectivity over caspases-8 and -9 (IC50 = 577.6 nM and 364.7 nM, respectively). Offers protection against Camptothecin (Cat. No. 208925), and anti-Fas-mediated apoptosis in Jurkat T cells.
A tetrapeptidyl aldehyde that acts as a potent, reversible and active site binding inhibitor of caspases-3 and -7 (IC50 = 3.2 nM and 22.6 nM, respectively) and displays ~100-fold greater selectivity over caspases-8 and -9 (IC50 = 577.6 nM and 364.7 nM, respectively). Offers protection against Camptothecin (Cat. No. 208925), and anti-Fas-mediated apoptosis in Jurkat T cells.

Note: aldehyde-based inhibitors are less cell-permeable than FMK-based inhibitors, so higher concentrations may be required for cell-based inhibition studies (e.g. 100 µM).

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Target IC50: 3.2 nM and 22.6 nM, against caspases-3 and -7, respectively
Product does not compete with ATP.
Reversible: yes
Primary Target
caspase-3, caspase-7
Cell permeable: no

警告

Toxicity: Standard Handling (A)

序列

Ac-Asp-Asn-Leu-Asp-CHO

分析说明

Single main spot with additional trace spot by TLC

其他说明

Yoshimori, A., et al. 2004. BMC Pharmacol.4, 7.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C20H31N5O10
分子量501.49

产品性质

质量水平100
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 white
溶解性water: 1 mg/mL
DMSO: 5 mg/mL
运输ambient
储存温度−20℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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