Clasto-乳胞素 β-内酯

产品名称：

154226-60-5
clasto-Lactacystin β-lactone
(1R,4R,5S)-1-[(1S)-1-Hydroxy-2-Methylpropyl]-4-Methyl-6-Oxa-2-Azabicyclo[3.2.0]Heptane-3,7-Dione
Omuralide
Clasto-乳胞素 β-内酯

产品介绍：

产品说明

应用

Clasto-Lactacystin β-lactone has been used as a protein degradation inhibitor to test its effect on memory improvements in mice. It has also been used as a proteasome inhibitor in human ovarian surface epithelium (HOSE) cells and dendritic cells (DCs).
Clasto-乳胞素 β-内酯用作蛋白酶体抑制剂。

生化/生理作用

细胞渗透性和不可逆蛋白酶体抑制剂。乳胞素作为染色体断裂-乳胞素 β 的前体-内酯。
Clasto-Lactacystin β-lactone (cLβL) is synthesized from lactacystin. It is cell-permeable and cLβL acts on the N-terminal threonine of subunit proteasome β -subunit X It also inhibits 20S proteasome activity in Haloferax volcanii by acting in the N-threonine residue of the β -type subunits.

基本信息

经验(实验)分子式	C₁₀H₁₅NO₄
分子量	213.23
MDL编号	MFCD01076526
PubChem化学物质编号	24896450
NACRES	NA.77

产品性质

质量水平	100
测定	≥95% (HPLC)
形式	film
溶解性	DMSO: soluble 25 mg/mL
储存温度	−20℃
SMILES string	[H][C@@]12OC(=O)[C@@]1(NC(=O)[C@@H]2C)[C@@H](O)C(C)C
InChI	1S/C10H15NO4/c1-4(2)6(12)10-7(15-9(10)14)5(3)8(13)11-10/h4-7,12H,1-3H3,(H,11,13)/t5-,6+,7+,10-/m1/s1
InChI key	FWPWHHUJACGNMZ-NBBQQVJHSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H319
预防措施声明	P264 - P280 - P305 + P351 + P338 - P337 + P313
危险分类	Eye Irrit. 2
储存分类代码	11 - Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable