产品说明
应用
Human cyclin-dependent kinase 5 has been used in a study to determine its 3′ untranslated region subunit 1 contains regulatory elements that affect transcript stability.
生化/生理作用
CDK5 is highly expressed in the nervous system where it phosphorylates a multitude of substrates. CDK5 plays an important role in many processes such as: apoptosis, phototransduction, dopamine and glutamate signalling, neurite outgrowth, neurone migration, induction of acetylcholine receptors, golgi membrane traffic and insulin exocytosis. It has also been implicated in the pathogenesis of amyotrophic lateral sclerosis . It is activated by p35 and p39, and their proteolytic cleavage products, p25 and p29.
单位定义
One unit will phosphorylate 1.0 picomole of the peptide substrate histone H19-18 per minute at 30 ℃ at pH 7.4.
外形
Supplied as a solution in PBS pH 7.4, 1 mM EDTA, 1mM DTT and 1 mg/ml BSA
基本信息
| MDL编号 | MFCD06201997 |
| NACRES | NA.54 |
产品性质
| 质量水平 | 200 |
| 重组 | expressed in E. coli BL21 |
| 形式 | solution |
| specific activity | 50-100 units/μg protein |
| 包装 | vial of 300 units |
| 运输 | dry ice |
| 储存温度 | −70℃ |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
Sigma-Aldrich
m.cnreagent.com
