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Cyclin-Dependent Kinase 5 human

品牌
Sigma-Aldrich
货号
C8739
规格纯度
recombinant, expressed in E. coli BL21, 50-100 units/μg protein
参考价格
9244.24 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Cyclin-Dependent Kinase 5 human
产品介绍:

产品说明

应用

Human cyclin-dependent kinase 5 has been used in a study to determine its 3′ untranslated region subunit 1 contains regulatory elements that affect transcript stability.

生化/生理作用

CDK5 is highly expressed in the nervous system where it phosphorylates a multitude of substrates. CDK5 plays an important role in many processes such as: apoptosis, phototransduction, dopamine and glutamate signalling, neurite outgrowth, neurone migration, induction of acetylcholine receptors, golgi membrane traffic and insulin exocytosis. It has also been implicated in the pathogenesis of amyotrophic lateral sclerosis . It is activated by p35 and p39, and their proteolytic cleavage products, p25 and p29.

单位定义

One unit will phosphorylate 1.0 picomole of the peptide substrate histone H19-18 per minute at 30 ℃ at pH 7.4.

外形

Supplied as a solution in PBS pH 7.4, 1 mM EDTA, 1mM DTT and 1 mg/ml BSA

基本信息

MDL编号MFCD06201997
NACRESNA.54

产品性质

质量水平200
重组expressed in E. coli BL21
形式solution
specific activity50-100 units/μg protein
包装vial of 300 units
运输dry ice
储存温度−70℃

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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