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Ganciclovir ready made solution

品牌
Sigma-Aldrich
CAS
82410-32-0
货号
SML2346
规格纯度
≥99% (HPLC), 10 mM in DMSO
参考价格
957.53 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
82410-32-0
Ganciclovir ready made solution
9-(1,3-Dihydroxy-2-propoxymethyl)guanine
DHPG
2-Amino-1,9-dihydro-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6H-purin-6-one
产品介绍:

产品说明

应用

Ganciclovir ready-made solution has been used in combination with resveratrol to study its effect on melanoma cells. It has also been used as a synthetic substrate for viral thymidine kinase to study its effects on human-inducible pluripotent stem cells.

生化/生理作用

Ganciclovir is a nucleoside guanosine analog that contains an active moiety, ganciclovir triphosphate. This active moiety can inhibit viral replication by interrupting the viral DNA during elongation. Ganciclovir is a potent agent in preventing cytomegalovirus (CMV) retinitis disease in human immunodeficiency virus (HIV) patients. It exhibits therapeutic effects against CMV disease involving the lungs, liver, and gastrointestinal tract. Ganciclovir can be enzymatically phosphorylated to an active triphosphate analog by herpes simplex virus thymidine kinase (HSV-TK) or host-encoded deoxyguanosine kinase. It has the potential to treat allogeneic bone marrow, kidney, heart, liver, and lung transplantations.

其他说明

Ganciclovir ready made solution in DMSO is provided at 10mM concentration (2.55mg/mL). It is suggested to dilute the provided ready made solution to a working concentration of 2-100μM for cell culture applications.

基本信息

经验(实验)分子式C9H13N5O4
分子量255.23
MDL编号MFCD12197280
NACRESNA.77

产品性质

测定≥99% (HPLC)
形式DMSO solution
浓度10 mM in DMSO
储存温度2-8℃
InChI1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17)
InChI keyIRSCQMHQWWYFCW-UHFFFAOYSA-N

安全信息

象形图GHS08
警示用语:Danger
危险声明H340
预防措施声明P201 - P202 - P280 - P308 + P313 - P405 - P501
危险分类Muta. 1B
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 2
闪点(F)188.6 °F - closed cup
闪点(C)87 ℃ - closed cup

Sigma-Aldrich

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