产品说明
应用
Swainsonine is an indolizidine alkaloid from the plant Metarrhizium anisopliae that is used as a potent α-mannosidase inhibitor. Product S8195 has been used in chemical inhibition assays of CHO Lec2 cells to inhibit glycosylation .
苦马豆素是各种α-甘露糖苷酶的有效抑制剂，特别是α-甘露糖苷酶II。它能够抑制糖蛋白加工，也可作为免疫调节剂。
生化/生理作用
Swainsonine is a potent α-mannosidase inhibitor. It also has antimetastatic, antiproliferative, and immunomodulatory activity . It also inhibits glycoprotein processing.
包装
1MG
制备说明
Soluble in water, methanol, DMSO
其他说明
Keep container tightly closed in a dry and well-ventilated place.
基本信息
| 经验(实验)分子式 | C8H15NO3 |
| 分子量 | 173.21 |
| Beilstein | 4175740 |
| MDL编号 | MFCD00017554 |
| PubChem化学物质编号 | 24899779 |
| NACRES | NA.85 |
产品性质
| 质量水平 | 200 |
| 生物来源 | Metarrhizium anisopliae |
| 测定 | ≥98% (TLC) |
| 形式 | lyophilized powder |
| 储存条件 | (Keep container tightly closed in a dry and well-ventilated place.) |
| 颜色 | white to faint yellow |
| 溶解性 | H2O: soluble 1 mg/mL |
| 作用机制 | enzyme | inhibits |
| 抗生素抗菌谱 | neoplastics |
| 储存温度 | 2-8℃ |
| SMILES string | O[C@@H]1CCCN2C[C@@H](O)[C@@H](O)C12 |
| InChI | 1S/C8H15NO3/c10-5-2-1-3-9-4-6(11)8(12)7(5)9/h5-8,10-12H,1-4H2/t5-,6-,7?,8-/m1/s1 |
| InChI key | FXUAIOOAOAVCGD-DCDLSZRSSA-N |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
Sigma-Aldrich
m.cnreagent.com
