2,2′-(2-Oxo-1,3-propanediyl)bis[N-[(phenylmethoxy)carbonyl]-L-leucyl-L-leucinamide

产品名称：

313664-40-3
(Z-LL)2 Ketone
2,2′-(2-Oxo-1,3-propanediyl)bis[N-[(phenylmethoxy)carbonyl]-L-leucyl-L-leucinamide
(Z-Leu-Leu-NHCH2)2CO
1,3-Di-(N-Carboxybenzoyl-L-leucyl-L-leucyl)amino Acetone

产品介绍：

产品说明

包装

1 mg in glass bottle

生化/生理作用

(Z-LL)2 Ketone is a selective inhibitor of signal peptide peptidase (SPP) that inhibits processing of the p-Prl signal peptide (IC₅₀ = ~ 50 nM) without affecting the activities of signal peptidases and other proteases such as lysosomal cathepsins and proteasomes.
(Z-LL)2 Ketone serves as an inverse γ-secretase modulator (iGSM) by changing processivity of γ-secretase cleavage.

基本信息

经验(实验)分子式	C₄₃H₆₄N₆O₉
分子量	809.00
MDL编号	MFCD04974180
PubChem化学物质编号	329825882

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to light yellow
运输	wet ice
储存温度	−20℃
SMILES string	O=C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(NCC(CNC([C@H](CC(C)C)NC([C@H](CC(C)C)NC(OCC1=CC=CC=C1)=O)=O)=O)=O)=O)=O)OCC2=CC=CC=C2
InChI	1S/C43H64N6O9/c1-27(2)19-34(46-40(53)36(21-29(5)6)48-42(55)57-25-31-15-11-9-12-16-31)38(51)44-23-33(50)24-45-39(52)35(20-28(3)4)47-41(54)37(22-30(7)8)49-43(56)58-26-32-17-13-10-14-18-32/h9-18,27-30,34-37H,19-26H2,1-8H3,(H,44,51)(H,45,52)(H,46,53)(H,47,54)(H,48,55)(H,49,56)/t34-,35-,36-,37-/m0/s1
InChI key	JTVCWQUNPMKMER-BQYLNSIHSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable