26,26,26,27,27,27-hexadeuterocholest-5-ene-3β,25-diol; 25-hydroxycholest-5-en-3-ol(d6)

产品名称：

88247-69-2
25-hydroxycholesterol-d6
26,26,26,27,27,27-hexadeuterocholest-5-ene-3β,25-diol; 25-hydroxycholest-5-en-3-ol(d6)

产品介绍：

产品说明

一般描述

25-hydroxycholesterol (25HC) is synthesized from cholesterol in the presence of oxygen and enzyme cholesterol 25-hydroxylase and the conversion is dependent on nicotinamide adenine dinucleotide phosphate (NADPH) during toll-like receptor activation. 25HC is catabolized to 7α-hydroxylated sterol. 25-hydroxycholesterol-d6 is the deuterated form of 25-hydroxycholesterol.

应用

25-hydroxycholesterol-d6 has been used as an internal standard:

in the quantification of 25-OHC in jejunum samples by liquid chromatography with tandem mass spectrometry (LC-MS-MS)
in plasma samples by liquid chromatography-mass spectrometry analysis
for calibration curve generation for plasma oxysterol quantification

生化/生理作用

25-hydroxycholesterol is a liver X receptor ligand. This bioactive lipid regulates immune response and macrophages production from monocytes. 25-HC serves as an antiviral effector and may have therapeutic potential. It reduces cholesterol biosynthesis by inactivating sterol regulatory element binding protein and inhibits HMG-CoA reductase (HMGCR). 25-HC may play a protective role in myocardial ischemia-reperfusion injury by inhibiting apoptosis and regulating mitogen-activated protein kinase (MAPK) pathway.

包装

5 mL Amber Glass Screw Cap Vial (700053P-1mg)

基本信息

经验(实验)分子式	C₂₇H₄₀D₆O₂
分子量	408.69
NACRES	NA.25

产品性质

测定	>99% (TLC)
形式	powder
包装	pkg of 1 × 1 mg (700053P-1mg)
manufacturer/tradename	Avanti Polar Lipids 700053P
运输	dry ice
储存温度	−20℃

安全信息

储存分类代码	13 - Non Combustible Solids
闪点(F)	No data available
闪点(C)	No data available