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位置:首页 > 品牌 > Sigma-Aldrich > 25,26,26,26,27,27-hexadeuterocholest-5-ene-3β,27-diol; 27-hydroxycholest-5-en-3-ol(d6); 111011

27-hydroxycholesterol-d6

品牌
Avanti
CAS
1246302-95-3
货号
700059P
规格纯度
25,26,26,26,27,27-hexadeuterocholest-5-ene-3β,27-diol, powder
参考价格
4213.19 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
1246302-95-3
27-hydroxycholesterol-d6
25,26,26,26,27,27-hexadeuterocholest-5-ene-3β,27-diol; 27-hydroxycholest-5-en-3-ol(d6); 111011
产品介绍:

产品说明

一般描述

27-hydroxycholesterol (27-HC) is synthesized from cholesterol by the action of sterol 27-hydroxylase in the liver. It is an abundant oxysterol in the circulation ranging from 0.15 to 0.73 μM. 27-HC serves as a substrate for bile synthesis. 27-hydroxycholesterol-d6 is a deuterated form of 27-hydroxycholesterol.

应用

27-hydroxycholesterol-d6 has been used:

  • as an internal standard in isotope dilution-mass spectrometry analysis of heart mitochondria samples
  • as an internal standard in gas chromatography-mass spectrometry (GC–MS) for plasma sterol quantification
  • as a deuterated internal standard for spiking plasma samples for liquid chromatography with tandem mass spectrometry (LC-MS-MS) analysis

生化/生理作用

27-hydroxycholesterol (27-HC) is a weak liver X receptor (LXR) agonist and a selective estrogen receptor modulator (SERM). Elevated levels of 27-HC is observed in hypercholesterolemia. 27-HC is implicated in breast cancer tumor and glioblastoma progression. 27-HC may help in treating non-alcoholic steatohepatitis. Elevated levels of 27-HC is associated with atherosclerotic lesions.

包装

5 mL Amber Glass Screw Cap Vial (700059P-1mg)

基本信息

经验(实验)分子式C27H40D6O2
分子量408.69
NACRESNA.25

产品性质

测定>99% (TLC)
形式powder
包装pkg of 1 × 1 mg (700059P-1mg)
manufacturer/tradenameAvanti Polar Lipids 700059P
运输dry ice
储存温度−20℃
SMILES string[H][C@@]12[C@]([C@](CC[C@H](O)C3)(C)C3=CC2)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCC[C@@]([2H])(C([2H])([2H])[2H])C(O)([2H])[2H]

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)No data available
闪点(C)No data available

Sigma-Aldrich

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