7β-hydroxycholesterol-d7

产品说明

一般描述

7β-hydroxycholesterol (7βOHC) is an oxidized derivative of cholesterol. 7β-hydroxycholesterol-d7 is the deuterated form of 7β-hydroxycholesterol.

应用

7β-hydroxycholesterol-d7 has been used:

• as cholesterol oxidation product for mass spectroscopy analysis
• as an internal standard for spiking white adipose tissue and plasma samples for mass spectroscopy analysis
• as an internal standard working solution in gas chromatography- triple-quadrupole mass spectrometry
• as an isotopically labeled internal standard in tandem mass spectroscopy analysis for plasma sterol quantification

生化/生理作用

7β-hydroxycholesterol-d7 (7β-OHC) along with 7-ketocholesterol (7-KC) plays a key role in atherogenesis. It is distributed extensively in the arterial compartment of apo- E knockout mice. 7βOHC induces apoptosis via activation of glycogen synthase kinase-3 (GSK3). It also triggers reactive oxygen species (ROS) resulting in mitochondrial dysfunction. 7βOHC favors demyelination and is a potential oxidized oxysterol in X-linked adrenoleukodystrophy (X-ALD) disorder.

包装

5 mL Amber Glass Screw Cap Vial (700044P-1mg)

基本信息

产品性质

安全信息