产品说明
一般描述
Sphinogmyelin, a sphingolipid consisting of a phospholipid (typically phosphocholine) attached to a ceramide moiety, is a major component of cellular membranes. Sphingomylein is enriched in the exoplasmic leaflet of the cell membrane. Within the cell membrane, sphingomyelin interacts with cholesterol to form lipid rafts. The metabolism of sphingomyelin contributes to cellular signaling via the release of ceramide, a second messenger that participates in multiple cellular signaling pathways. Sphingomyelin accumulates in Niemann-Pick disease due to deficiencies in sphingomyelinase activity.
适用性
本试剂盒适于检测多种样品中的鞘磷脂，如血液及细胞提取物等。
原理
Sphingomyelin is determined by a coupled enzyme assay, in which the hydrolysis of sphingomyelin by sphingomyelinase produces phosphocholine, which results in a fluorescent product (λex =540/λem = 590 nm) proportional to the Sphingomyelin present.
基本信息
| NACRES | NA.84 |
产品性质
| 用途 | sufficient for 100 fluorometric tests |
| detection method | fluorometric |
| 储存温度 | −20℃ |
安全信息
| 象形图 |     |
| 警示用语： | Danger |
| 危险声明 | H302 - H317 - H318 - H334 - H410 |
| 预防措施声明 | P261 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 |
| 危险分类 | Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Sens. 1 |
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 3 |
Sigma-Aldrich
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