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Human NELL-1 ELISA

品牌
Sigma-Aldrich
货号
RAB1590
包装型号
规格纯度
参考价格
8768.8 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Human NELL-1 ELISA
人NELL-1 ELISA
产品介绍:

产品说明

一般描述

This ELISA antibody pair detects human NELL-1. Other species are not determined.
The NELL-1 (neural EGFL like 1) gene encodes an extracellular glycoprotein and is mapped to human chromosome 11p15. Nell-1 is a 810 amino acids protein containing thrombospondin-1 module at its N-terminus and includes other motifs : five von Willebrand factor C domains and six epidermal growth factor (EGF)-like domains.

应用

For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.

生化/生理作用

NELL-1 (neural EGFL like 1) is associated with the risk of Rhabdomyosarcomas and the gene is identified to be hypomethylated. The protein encoded influences osteogenic related processes and thus loss of the NELL-1 gene function leads to abnormality in bone and cartilage. NELL-1 is considered as a essential factor in skeletal development as it controls the action of runt-related transcription factor 2. Lack of Nell-1 protein decreases the expression of gene encoding cartilage proteins such as collagens, tenascins, matrilins, and chondroadherin. It serves as an important growth factor in promoting regeneration of articular cartilage. NELL-1 is a tumor suppressor gene and hypermethylation of its promoter region indicates poor prognosis of the disease in esophageal adenocarcinoma.

其他说明

A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.

基本信息

NACRESNA.32

产品性质

species reactivityhuman
包装kit of 96 wells (12 strips x 8 wells)
technique(s)ELISA: suitable
inputsample type plasma
sample type cell culture supernatant(s)
sample type serum
assay rangeinter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 10 pg/ml
detection methodcolorimetric
运输wet ice
储存温度−20℃
Gene Informationhuman ... NELL1(4745)

安全信息

象形图GHS05
警示用语:Warning
危险声明H290
预防措施声明P234 - P390
危险分类Met. Corr. 1
储存分类代码8A - Combustible, corrosive hazardous materials
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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