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位置:首页 > 品牌 > Sigma-Aldrich > 贯叶金丝桃素 二环己基铵盐

Hyperforin (dicyclohexylammonium) salt

贯叶金丝桃素 二环己基铵盐

品牌
Sigma-Aldrich
CAS
238074-03-8
货号
H1792
包装型号
规格纯度
参考价格
3875.37 *本价格含增值税费
促销
服务
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数量
-+
产品名称:
238074-03-8
Hyperforin (dicyclohexylammonium) salt
Hyperforin-DCHA
Hyp-DCHA
贯叶金丝桃素 二环己基铵盐
产品介绍:

产品说明

包装

1 mg in glass bottle

生化/生理作用

Stable salt of hyperforin. Hyperforin is believed to be the primary active constituent responsible for the antidepressant and anxiolytic properties of the extracts of St. John′s wort. It acts as a reuptake inhibitor of monoamines, including serotonin, norepinephrine, dopamine, and of GABA and glutamate by activating the transient receptor potential ion channel TRPC6. Activation of TRPC6 induces the entry of sodium and calcium into the cell which causes inhibition of monoamine reuptake. It also is an activator of the pregnane X receptor (PXR), which serves as a key regulator of CYP3A4 transcription, a member of the cytochrome (CYP) P450 enzyme system. Recent studies have found other neurological effects, effects on inflammation, as well as antibacterial, antitumoral and antiangiogenic effects.
Hyperforin is believed to be the primary active constituent responsible for the antidepressant and anxiolytic properties of the extracts of St. John′s wort. It acts as a reuptake inhibitor of monoamines, including serotonin, norepinephrine, dopamine, and of GABA and glutamate by activating the transient receptor potential ion channel TRPC6. It also is an activator of the pregnane X receptor (PXR), which serves as a key regulator of CYP3A4 transcription, a member of the cytochrome (CYP) P450 enzyme system. Recent studies have found it to have neuroprotective effects against Alzheimer′s disease (AD) neuropathology, including the ability to disassemble amyloid-β aggregates in vitro and improve spatial memory in vivo.

基本信息

经验(实验)分子式C35H52O4·C12H23N
分子量718.10
MDL编号MFCD04000098
PubChem化学物质编号329815179
NACRESNA.25

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
储存条件protect from light
颜色 white to off-white
溶解性DMSO: ≥10 mg/mL
储存温度−20℃
SMILES stringC1CCC(CC1)NC2CCCCC2.CC(C)C(=O)[C@@]34C(O)=C(C\C=C(\C)C)C(=O)[C@@](C\C=C(\C)C)(C[C@H](C\C=C(/C)C)[C@@]3(C)CC\C=C(\C)C)C4=O
InChI1S/C35H52O4.C12H23N/c1-22(2)13-12-19-33(11)27(16-14-23(3)4)21-34(20-18-25(7)8)30(37)28(17-15-24(5)6)31(38)35(33,32(34)39)29(36)26(9)10;1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h13-15,18,26-27,38H,12,16-17,19-21H2,1-11H3;11-13H,1-10H2/t27-,33+,34+,35-;/m0./s1
InChI keyZUYCAROZOLUHJY-DNSWOBEMSA-N

安全信息

象形图GHS05GHS07GHS09
警示用语:Danger
危险声明H302 - H314 - H400
预防措施声明P260 - P273 - P280 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338
危险分类Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Dam. 1 - Skin Corr. 1B
储存分类代码8A - Combustible, corrosive hazardous materials
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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