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C-Peptide EIA Kit

品牌
Sigma-Aldrich
货号
RAB0326
规格纯度
for serum, plasma, culture supernatant and cell lysates
参考价格
7571 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
C-Peptide EIA Kit
产品介绍:

产品说明

一般描述

The C-Peptide Enzyme Immunoassay (EIA) Kit is an in vitro quantitative assay for detecting C-Peptide peptide based on the principle of Competitive Enzyme Immunoassay. EIA-CPE-1 only detects C-peptide, not Insulin A or B chain.

免疫原

C-Peptide , synthetic peptide

应用

请参考Protocol了解详情。

生化/生理作用

C-peptide inhibits endothelial dysfunction under high glucose conditions via inhibition of nuclear factor-κB (NF-κB) pathway. Experimental studies suggest that prolonged dosage of physiological concentration of C-peptide to type 1 diabetes patients minimizes diabetes-induced complications, such as glomerular hypertrophy and mesangial matrix expansion by interrupting transforming growth factor β1 (TGF-β1) and tumor necrosis factor α (TNFα) signaling pathway. C-peptide reduces diabetes-induced glomerular hyperfiltration by contraction of the afferent arteriole, dilation of the efferent arteriole, and by inhibition of tubular reabsorption. C-Peptide also plays a crucial role in renal pathophysiology. C-peptide binds to a cell surface receptor that is likely to be G-protein coupled. This interaction stimulates various cellular functions such as increasing intracellular Ca2+ concentration, enhancing PI3-K (phosphoinositide 3-kinase) activity, increased endothelial nitric oxide synthase (eNOS) transcription, and activation of the Na+/K+ ATPase and mitogen-activated protein kinase (MAPK) signaling pathway.

基本信息

NACRESNA.32

产品性质

species reactivityhuman, rat, mouse
包装kit of 96 wells (12 strips x 8 wells)
technique(s)ELISA: suitable
enzyme immunoassay: suitable
inputsample type cell lysate
sample type culture supernatant(s)
sample type plasma
sample type serum
assay rangeinter-assay cv: <15%
intra-assay cv: <10%
sensitivity: 772 pg/mL
standard curve range: 0.1-1000 ng/mL
detection methodcolorimetric
运输wet ice
储存温度−20℃
Gene Informationhuman ... INS(3630)

组份列表

组份可单独销售

货号组份
RABHRP3HRP-Streptavidin

安全信息

象形图GHS05
警示用语:Warning
危险声明H290
预防措施声明P234 - P390
危险分类Met. Corr. 1
储存分类代码8A - Combustible, corrosive hazardous materials
WGKWGK 3

Sigma-Aldrich

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