C8 Ceramide-1-Phosphate (d18:1/8:0)

产品说明

一般描述

C8 Ceramide-1-Phosphate (d18:1/8:0) or N-octanoyl-ceramide-1-phosphate is a synthetic short-chain ceramide.
Ceramide-1-phosphate is synthesized from ceramide by the phosphorylation reaction catalyzed by ceramide kinase (CerK).

应用

C8 Ceramide-1-Phosphate (d18:1/8:0) or N-octanoyl-ceramide-1-phosphate has been used:

• in lipid preparation to treat endothelial colony-forming cells (ECFCs) for nuclear morphology analysis
• for the validation of C8 ceramide-1-phosphate metabolite to study its effects on the metabolic pathways of Rana catesbeiana during metamorphosis
• to screen lipids that rapidly and reversibly alter transepithelial electrical resistance (TER) or tight junction (TJ) permeability in epithelial tissue

C8 Ceramide-1-Phosphate (d18:1/8:0) has been used as one of the authentic standards to validate selected metabolites in metabolomic study of vertebrate metamorphosis.

生化/生理作用

Ceramide-1-phosphate (C1P), as a lipid derived secondary messenger plays a vital role in various cellular processes such as inflammation, cell proliferation, differentiation and apoptosis. It is mitogenic for fibroblasts. C1P is also implicated in the modulation of macrophage chemotaxis. It promotes cell-survival by inhibiting the enzyme acid sphingomyelinase (SMase).

包装

5 mL Amber Glass Screw Cap Vial (860532P-1mg)

基本信息

经验(实验)分子式	C26H55N2O6P
分子量	522.70
NACRES	NA.25

产品性质

形式	powder
包装	pkg of 1 × 1 mg (860532P-1mg)
manufacturer/tradename	Avanti Polar Lipids 860532P
运输	dry ice
储存温度	−20℃
SMILES string	[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCC)=O)COP([O-])(O)=O.[NH4+]

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3