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cholestenoic acid-d5

品牌
Avanti
CAS
1620239-03-3
货号
700151P
规格纯度
3β-hydroxy-5-cholestenoic acid-d5, powder
参考价格
4229.01 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
1620239-03-3
cholestenoic acid-d5
产品介绍:

产品说明

一般描述

Cholestenoic acid-d5 is an endogenous cholesterol metabolite. It is produced in extrahepatic organs.
Cholestenoic acid levels in plasma ranges between 100-300 nM and is synthesized in brain. Cholestenoic acid is generated by the side chain oxidation of 27-hydroxy-cholesterol and is an intermediate in the bile synthesis pathway.

生化/生理作用

Cholestenoic acid-d5 functions as a potent steroid γ-secretase modulator (GSM).
Cholestenoic acid is a carboxylic acid γ-secretase modulator. Cholestenoic acid also serves as a ligand for liver X receptor. Cholestenoic acid -d5 regulates amyloid β peptides (Aβ) levels. It reduces Aβ42 levels and enhances Aβ38 levels. In retina, it is the major byproduct of cholesterol elimination. 27-hydroxycholesterol and cholestenoic acid are part of reverse cholesterol transport in macrophages and their transport impairment is implicated in premature atherosclerosis.

包装

5 mL Amber Glass Screw Cap Vial (700151P-1mg)

基本信息

经验(实验)分子式C27H39 D5O3
分子量421.67
NACRESNA.25

产品性质

测定>99% (TLC)
形式powder
包装pkg of 1 × 1 mg (700151P-1mg)
manufacturer/tradenameAvanti Polar Lipids 700151P
运输dry ice
储存温度−20℃

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3

Sigma-Aldrich

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