产品说明
一般描述
The Human CD26 (also known as DPPIV) ELISA (Enzyme- Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human CD26 in serum, plasma, cell culture supernatants and urine.
免疫原
Recombinant Human CD26
应用
请参考Protocol了解详情。
生化/生理作用
Dipeptidyl peptidase 4 (DPPIV), also known as CD26 (cluster of differentiation 26), is localized on T- cell surface and interacts with adenosine deaminase (ADA), collagen and CD459. It plays a vital role in T cell co-stimulation, cell-to-cell adhesion, and in human immunodeficiency virus (HIV) infection. Deletion of the DPPIV gene alters carbohydrate metabolism which in turn leads to mental retardation and hypotonia. Abnormal expression of DPPIV is observed during liver regeneration, human cirrhosis and liver tumorigenesis. DPPIV level is reduced in serum of chronic obstructive pulmonary disease (COPD) patients, hence, this protein has potential as a serologic marker for screening COPD. DPP4 functions as a serine protease enzyme that catalyzes the cleavage of dipeptides from peptides containing proline or alanine residues. IL-13 induced DPPIV expression is upregulated in bronchial epithelial cells (BECs) and this expression might contribute to the development of asthmatic airway inflammation, cell proliferation and fibronectin (FN) production. This protein is a promising biomarker and therapeutic target for asthma.
其他说明
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
基本信息
| NACRES | NA.32 |
产品性质
| species reactivity | human |
| 包装 | kit of 96 wells (12 strips x 8 wells) |
| technique(s) | ELISA: suitable capture ELISA: suitable |
| input | sample type urine sample type plasma sample type serum sample type cell culture supernatant(s) |
| assay range | inter-assay cv: <12% intra-assay cv: <10% sensitivity: 25 pg/mL standard curve range: 32.77-8000 pg/mL |
| detection method | colorimetric |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... DPP4(1803) |
组份列表
组份可单独销售
| 货号 | 组份 |
| RABELADA | ELISA 1X Assay/Sample Diluent Buffer A (Item D1) |
| RABELADB | ELISA 5X Assay/Sample Diluent Buffer B (Item E1) |
| RABSTOP3 | ELISA Stop Solution (Item I) |
| RABTMB3 | ELISA Colorimetric TMB Reagent (HRP Substrate, Item H) |
| RABWASH4 | 20X Wash Buffer (Item B) |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H290 |
| 预防措施声明 | P234 - P390 |
| 危险分类 | Met. Corr. 1 |
| 储存分类代码 | 8A - Combustible, corrosive hazardous materials |
| WGK | WGK 3 |
Sigma-Aldrich
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