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MRP3 Knockout Caco-2 Cells

品牌
Sigma-Aldrich
货号
MTOX1093
包装型号
规格纯度
one vial
参考价格
26652.2 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
MRP3 Knockout Caco-2 Cells
产品介绍:

产品说明

一般描述

The C2BBe1 cells, a subclone of Caco-2 cells, correspond to ATCC CRL-2102. The MRP3 knockout C2BBe1 cells are adenocarcinoma, epithelial cells from a human caucasian male (aged 72 years) with functional knockout of the ABCC3 (MRP3) efflux transporter.

应用

The following posters and articles demonstrate how Caco-2 cells can be used for cell based assays:

Transporter Function in Caco-2 Cells with Targeted P-Glycoprotein, MRP2 and BCRP Gene Knockout Using Zinc Finger Nucleases

Comparison of Function and Relative Transporter Protein Concentrations in Caco-2 Cells with Single and Double Knockouts of the ABCB1, ABCG2, and ABCC2 Genes

Caco-2 Transporter Knockout Cell Based Assays

特点和优势

The Caco-2 subclone C2BBe1 cells are ideal for transporter analysis as they express multiple transporters, are human derived, and grow in a homogenous monolayer that forms tight junctions necessary for efflux ratio analysis. Other benefits include:

  • A functional knockout of the MRP3 gene eliminates the reliance on chemical inhibitors to determine if a compound is an MRP3 substrate
  • The vial format enables the MRP3 knockout cells to be included in standard drug transporter protocols
  • Human assay with no interference from animal inhibitors
  • Overcome the limitations of RNAi and knockdown cell lines that arise from remaining transporter functionality

法律信息

ADME/Tox Cell Lines License

基本信息

NACRESNA.81

产品性质

质量水平200
生物来源human male colorectal tissue (Source Disease: colon adenocarcinoma)
形式liquid
technique(s)drug transporter assay: suitable
permeability assay: suitable
application(s)ADME/TOX
储存温度−196℃
Gene Informationhuman ... ABCC3(8714)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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