产品说明
一般描述
The Phospho-Stat1 (pSer727) ELISA (Enzyme-Linked Immunosorbent Assay) kit is a very rapid, convenient and sensitive assay kit that can monitor the activation or function of important biological pathways in cell lysates.
免疫原
Stat1 (pTyr727) synthetic phosphopeptide, Recombinant Human STAT1
应用
请参考Protocol了解详情。
生化/生理作用
Signal transducer and activator of transcription 1 (STAT1) undergoes phosphorylation on serine-727. This Phospho-Stat1 regulates pro- and anti-apoptotic genes following several stress-induced responses. STAT-1 interacts with p53 and promotes p53-mediated transcriptional gene activity and apoptosis. STAT-1 is an essential factor of stress-induced and DNA damage-induced checkpoint pathways and thus, acts as a tumour suppressor. STAT-1 functions as a pro-apoptotic factor in cardiac myocytes, brain or liver exposed to ischaemia–reperfusion injury. Thus, inhibition of STAT-1-activated pathway by epigallocatechin-3-gallate (EGCG), can be considered as a potential therapeutic method against ischaemic tissue injury. Repression of STAT-1 expression by human papillomavirus (HPV) oncoproteins E6 and E7 at transcription level is essential for genome amplification and maintenance of episomes, which is suggested to have a crucial role in viral pathogenesis.
基本信息
| NACRES | NA.32 |
产品性质
| species reactivity | human, mouse |
| technique(s) | ELISA: suitable capture ELISA: suitable |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... STAT1(6772) mouse ... STAT1(20846) |
安全信息
| 象形图 |   |
| 警示用语： | Warning |
| 危险声明 | H290 - H335 |
| 危险分类 | Met. Corr. 1 - STOT SE 3 |
| 靶器官 | Respiratory system |
| 储存分类代码 | 8B - Non-combustible, corrosive hazardous materials |
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